Indiana University Purdue University Indianapolis

Stephen L Boehm II Ph.D.

Director of Neuroscience Program; Associate Professor, Psychology

Education

2002-2005 Postdoctoral, Behavioral and Molecular Pharmacology, University of Texas at Austin.

1996-2002 Behavioral Neuroscience Ph.D., Oregon Health & Science University, Portland.

1990-1996 Psychology B. A., University of Northern Colorado, Greeley.

Current Research

Work in my lab seeks to understand how developmental and genetic factors influence loss of control over alcohol intake, or binge drinking. Alcohol-related behaviors thought to influence propensity to engage in binge-like alcohol drinking in mice are studied. We use mice of different developmental and genetic backgrounds to ask mechanistic questions about the complex relationships between brain and behavior. For example, we compare different genetic mouse models to assess age-specific sensitivity to alcohol's behavioral actions and determine how alcohol exposure during prenatal and early postnatal development influences that of adulthood. Moreover, we employ state-of-the-art techniques to study the relationships between brain and behavioral sensitivity to alcohol in mice, including site-specific microinjection into discrete brain regions and ELISA analysis of protein expression across brain structures to determine which neurotransmitter systems and brain structures are important modulators of alcohol-related behavior. Our hope is that such work will help elucidate the behavioral/brain mechanisms associated with alcohol behavioral sensitivity in humans and provide further insight into how those mechanisms influence (and are influenced by) binge alcohol drinking across development. Our work is supported by grants from the National Institute on Alcohol Abuse and Alcoholism.

Select Publications

    1. †Fritz BM, Boehm II SL (2014) The effect of prior alcohol consumption on sensitivity and acute functional tolerance to alcohol-induced ataxia in High Alcohol Preferring mice. Alcohol, in press.

    2. †Kasten CR, Boehm II SL (2014) Intra-nucleus accumbens shell injections of R(+)- and S(-)-baclofen bidirectionally alter binge-like ethanol, but not saccharin, intake in C57BL/6J mice. Behavioural Brain Research, 272:238-247. PMID:25026094

    3. †Fritz BM, Boehm II SL (2014) Site-specific microinjection of Gaboxadol into the infralimbic cortex modulates ethanol intake in male C57BL/6J mice. Behavioural Brain Research, 273:8-15. PMID:25043731

    4. †Fritz BM, *Companion M, Boehm II SL (2014) “Wired,” yet intoxicated: modeling binge caffeine and alcohol co-consumption in the mouse. Alcoholism: Clinical and Experimental Research, 38:2269-2278. PMID:24961658

    5. †Fritz BM, Cordero KA, Barkley-Levenson AM, Metten P, Crabbe JC, Boehm II SL (2014) Genetic relationship between predisposition for binge alcohol consumption and blunted sensitivity to adverse effects of alcohol in mice. Alcoholism: Clinical and Experimental Research, 38:1284-1292. PMID:24612020

    6. †Linsenbardt DN, Boehm II SL (2014) Alterations in the rate of (binge) ethanol consumption: Implications for preclinical studies in mice. Addiction Biology, 19:812-825. PMID:23742054

    7. †Linsenbardt DN, Boehm II SL (2013) Determining the heritability of ethanol-induced locomotor sensitization in mice using short-term behavioral selection. Psychopharmacology, 230:267-278. PMID:23732838.

    8. †Melón LC, *Wray KN, †Moore EM, Boehm II SL (2013) Sex and age differences in heavy binge drinking and its effects on alcohol responsivity following abstinence. Pharmacology, Biochemistry and Behavior, 104:177-187. PMCID: PMID:23333154

    9. †Fritz BM, Grahame NJ, Boehm II SL (2013) Selection for high alcohol preference drinking in mice results in heightened sensitivity and rapid development of acute functional tolerance to alcohol’s ataxic effects. Genes, Brain and Behavior, 12:78-86. PMID:22853703

    10. †Moore EM, *Forrest RD, Boehm II SL (2013) Genotype modulates age-related alterations in sensitivity to the aversive effects of ethanol: an eight inbred strain analysis of conditioned taste aversion. Genes, Brain and Behavior, 12:70-77. PMID:23171343

    11. *Kruse LC, †Linsenbardt DN, Boehm II SL (2012) Positive allosteric modulation of the GABAB receptor attenuates the locomtor stimulant actions of ethanol and alters the induction of locomotor sensitization. Alcohol, 46:455-462. PMID:22560291

    12. †Linsenbardt DN, Boehm II SL (2012) Role of novelty and ethanol history in locomotor stimulation induced by binge-like ethanol intake. Alcoholism: Clinical and Experimental Research, 36:887-94. PMID:22150802

    13. †Melón LC, Boehm II SL (2011) Development of locomotor sensitization to ethanol in adult and adolescent mice: Comparison of the DBA/2J and C57BL/6J inbred mouse strains. Alcoholism: Clinical and Experimental Research, 35:1351-60. PMID:21410489

    14. †Linsenbardt DN, † Moore EM, *Griffin KD, *Gigante E, Boehm II SL (2011) Tolerance to ethanol’s ataxic and locomotor effects following repeated binge-like ethanol intake using the DID model. Alcoholism: Clinical and Experimental Research, 35:1246-55. PMID:21410484

    15. †Melón LC, Boehm II SL (2011) GABAA receptors in the posterior, but not anterior, ventral tegmental area mediate Ro15-4513 attenuation of binge-like ethanol consumption in C57BL/6J female mice. Behavioural Brain Research, 220:230-237. PMID:21320533

    16. †Moore EM, †Linsenbardt DN, †Melón LC, Boehm II SL (2010) Ontogenetic differences in adolescent and adult C57BL/6J and DBA/2J mice: Anxiety-like, locomotor, and consummatory behaviors. Developmental Psychobiology, 53:141-56. PMID:20886536

    17. †Linsenbardt DN, Boehm II SL (2010) Ethanol-induced locomotor sensitization in DBA/2J mice is associated with alterations in GABAA subunit gene expression and behavioral sensitivity to GABAA acting drugs. Pharmacology, Biochemistry, and Behavior, 95:359-366. PMID:20219525

    18. †Moore EM, *Mariani J, †Linsenbardt DN, †Melón LC, Boehm II SL (2010) C57BL/6J (but not DBA/2J) C57BL/6J (but not DBA/2J) Mice consume greater amounts of limited-access ethanol compared to adults and display continued elevated ethanol intake into adulthood. Alcoholism: Clinical and Experimental Research, 34:1-9. PMID:20102570

    19. †Linsenbardt DN, Boehm II SL (2009) Agonism of the endocannabinoid system modulates binge-like alcohol intake in male C57BL/6J mice: Involvement of the posterior ventral tegmental area. Neuroscience, 164:424-434. PMID:2762022

    20. †Moore EM, Boehm II SL (2009) Site-specific microinjection of baclofen into the anterior ventral tegmental area reduces ethanol intake in male C57BL/6J mice. Behavioral Neuroscience, 123:555-563. PMCID: PMID:2732108

    21. †Linsenbardt DN, †Moore EM, *Gross CD, *Goldfarb KJ, †Blackman LC, Boehm II SL (2009) Sensitivity and tolerance to the hypnotic and ataxic effects of ethanol in adolescent and adult C57BL/6J and DBA/2J mice. Alcoholism: Clinical and Experimental Research, 33:1-13. PMID:2736547

      *Indicates undergraduate student

      †Indicates graduate student