Indiana University Purdue University Indianapolis

Christopher Lapish

Assistant Professor, Psychology

Education

Research Associate Professor, Brain Research Centre, University of British Columbia, 2008-2010
Postdoctoral, Brain Research Centre, University of British Columbia, 2006-2008
Ph.D., Medical University of South Carolina, 2002-2006, Neuroscience
B.S., Clemson University, Microbiology

Current Research

Multiple neuropsychiatric disorders are characterized by deficits in cognition. The primary focus of my research is to understand the neurophsyiological basis of cognition and explore potential procognitive treatment vectors for disorders such as schizophrenia and addiction. My lab performs electrophysiological recordings in areas of the brain known to perform computations necessary for various forms of cognition such as working memory and attention. I am especially interested in how the neurotransmitter dopamine influences interactions amongst large neural populations. Understanding how dopamine shapes the population dynamic is crucial to our understanding of cognition and how dopamine-mediated signaling may be altered in neuropsychiatric illness.

Select Publications

  • Lapish C.C., Ahn S., So K., Evangelista L.M., Seamans J.K., Phillips A.G. Tolcapone enhances food-evoked dopamine efflux and executive memory processes mediated by the rat prefrontal cortex. Psychopharmocology. 2008 October 18 (Epub). PMID: 18854987
  • Lapish C.C., Durstewtiz D., Chandler L.J., Seamans J.K. Successful choice behavior is associated with distinct and coherent network states in anterior cingulate cortex. Proc. Natl. Acad Sci. 2008 August 19;105(33): 11963-8. PMID: 18708525
  • Seamans J.K., Lapish C.C., Durstewitz D. Comparing the prefrontal cortex of rats and primates: insights from electrophysiology. Neurotoxicity Research. 2008, 14(03):249. PMID: 19073430
  • Lapish C.C., Kroener S., Durstewitz D., Lavin A., Seamans J.K. The ability of the mesocortical dopamine system to operate in distinct temporal modes.
    Psychopharmacology. 2007 Apr;191(3):609-25. Nov 4. PMID: 17086392